Let the Good Times Roll
I think I'm a sucker for graduation speeches. I thought Guy Kawasaki's was pretty good big-picture advice overall. It's worth reading his explanation of each point, but here's the list for reference:
"#10: Live off your parents as long as possible.
#9: Pursue joy, not happiness.
#8: Challenge the known and embrace the unknown.
#7: Learn to speak a foreign language, play a musical instrument, and play non-contact sports.
#6: Continue to learn.
#5: Learn to like yourself or change yourself until you can like yourself. #4: Don't get married too soon.
#3: Play to win and win to play.
#2: Obey the absolutes.
#1: Enjoy your family and friends before they are gone."
Via The Business of Life.